beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
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Overview
publication date
- January 1, 2001
published in
has subject area
- Alzheimer Disease
- Amino Acid Substitution
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Animals
- Apoptosis
- Aspartic Acid Endopeptidases
- Caspases
- Culture Media, Conditioned
- Endopeptidases
- Genetic Vectors
- Humans
- London
- Mutagenesis, Insertional
- Mutagenesis, Site-Directed
- Nerve Tissue Proteins
- Peptide Fragments
- Point Mutation
- Rats
- Simplexvirus
- Sweden
- Transgenes