A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.
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Overview
publication date
- January 2003
published in
- Journal of neurochemistry Journal
has subject area
- Autoantigens
- Blotting, Northern
- Blotting, Western
- Cell Line, Tumor
- Cycloheximide
- Electrophoresis, Gel, Pulsed-Field
- Humans
- In Vitro Techniques
- Intracellular Signaling Peptides and Proteins
- Leucine
- Methionine
- Mutation, Missense
- Oncogene Proteins
- Parkinsonian Disorders
- Phenylalanine
- Precipitin Tests
- Protein Deglycase DJ-1
- Protein Synthesis Inhibitors
- Proteins
- Proto-Oncogene Proteins c-myc
- RNA, Messenger
- Ribonucleoproteins
- SS-B Antigen
- Sulfur Isotopes
- Transfection