RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.
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Overview
publication date
- December 14, 2006
published in
has subject area
- Adaptor Proteins, Signal Transducing
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Cell Line, Tumor
- Humans
- Nerve Tissue Proteins
- Neuropeptides
- Nuclear Proteins
- Protein Binding
- Protein Processing, Post-Translational
- Protein Structure, Tertiary
- RNA Interference
- RNA, Small Interfering
- Shc Signaling Adaptor Proteins
- Species Specificity
- Src Homology 2 Domain-Containing, Transforming Protein 1
- Src Homology 2 Domain-Containing, Transforming Protein 3