ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.
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Overview
publication date
- January 1, 2008
published in
- Oncogene Journal
has subject area
- Amyloid Precursor Protein Secretases
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antineoplastic Combined Chemotherapy Protocols
- Breast Neoplasms
- Cell Death
- Drug Evaluation, Preclinical
- Drug Resistance, Neoplasm
- Enzyme Inhibitors
- Erb-b2 Receptor Tyrosine Kinases
- Gene Expression Regulation, Neoplastic
- Humans
- RNA, Small Interfering
- Receptor, Notch1
- Trastuzumab
- Tumor Cells, Cultured
- Up-Regulation