authors
- Liu, Wei Wei
- Todd, Stephen
- Coulson, David T R
- Irvine, G Brent
- Passmore, A Peter
- Bernadette McGuinness, MD, PhD
- McConville, Maeve
- Craig, David
- Johnston, Janet A
A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets.
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Overview
publication date
- January 2009
published in
- Journal of neurochemistry Journal
has subject area
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Aspartic Acid Endopeptidases
- Blood Platelets
- Case-Control Studies
- Cell Line, Tumor
- Cell Membrane
- Cholesterol
- Cognition Disorders
- Culture Media, Serum-Free
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Linear Models
- Male
- Neuroblastoma
- Statistics, Nonparametric
- Subcellular Fractions
- Time Factors
- beta-Cyclodextrins