authors
- Liu, Jianhua
- Ghavami, Afshin
- Lowe, David A
- Brunner, Dani
- Lukas, Ronald J
- Kozikowski, Alan P
- Yu, Li-Fang
- Eaton, J Brek
- Caldarone, Barbara
- Cavino, Katie
- Ruiz, Christina
- Terry, Matthew
- Fedolak, Allison
- Wang, Daguang
Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.
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Overview
publication date
- January 1, 2011
published in
- Journal of medicinal chemistry Journal
has subject area
- Animals
- Antidepressive Agents
- Azetidines
- Behavior, Animal
- Binding, Competitive
- Blood Proteins
- Drug Partial Agonism
- Humans
- In Vitro Techniques
- Isoxazoles
- Mice
- Microsomes, Liver
- Nicotinic Agonists
- Protein Binding
- Pyridines
- Rats
- Receptors, Neurotransmitter
- Receptors, Nicotinic
- Structure-Activity Relationship