Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
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Overview
publication date
- July 19, 2017
published in
has subject area
- Age Factors
- Animals
- Biomarkers
- Blood Glucose
- Female
- Genetic Predisposition to Disease
- In Vitro Techniques
- Insulin
- Insulin Resistance
- Leucine
- Lipid Metabolism
- Lysine
- Male
- Metabolism, Inborn Errors
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Knockout
- Mitochondrial Proteins
- Phenotype
- Protein Processing, Post-Translational
- Sirtuins
- Up-Regulation