authors
- Arra, Manoj
- Mbalaviele, Gabriel
- Shen, Jie
- Abu-Amer, Yousef
- Swarnkar, Gaurav
- Ke, Ke
- Otero, Jesse E
- Ying, Jun
- Duan, Xin
- Maruyama, Takashi
- Rai, Muhammad Farooq
- O'Keefe, Regis J
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.
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Overview
publication date
- July 9, 2020
published in
- Nature communications Journal
has subject area
- Adaptor Proteins, Signal Transducing
- Aerobiosis
- Animals
- Cartilage, Articular
- Cells, Cultured
- Chondrocytes
- Cytoprotection
- Gene Deletion
- Gene Expression Regulation
- Glycolysis
- Humans
- Inflammation
- Interleukin-1beta
- Knee Joint
- Lactate Dehydrogenase 5
- Menisci, Tibial
- Metabolic Networks and Pathways
- Mice, Inbred C57BL
- Molecular Targeted Therapy
- NAD
- NF-kappa B
- Osteoarthritis
- Reactive Oxygen Species