FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis.
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Overview
publication date
- November 16, 2020
published in
has subject area
- Animals
- Autophagy
- Biomarkers
- Cartilage, Articular
- Chondrocytes
- Disease Models, Animal
- Disease Susceptibility
- Forkhead Box Protein O1
- Forkhead Transcription Factors
- Homeostasis
- MAP Kinase Kinase Kinase 7
- MAP Kinase Kinase Kinases
- Mice
- Mice, Knockout
- Models, Biological
- Osteoarthritis
- Reactive Oxygen Species
- Signal Transduction
- Transforming Growth Factor beta
- X-Ray Microtomography