SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism. uri icon

authors

  • Goodson, Baley A
  • Ye, Chunyan
  • Kell, Alison M
  • Bradfute, Steven B
  • Lemus, Monica Rosas
  • Pu, Jing
  • Vazquez, Valeria Montenegro
  • Doyle, Aliza
  • Kolaczkowski, Oralia M
  • Liu, Rui
  • Jia, Jingyue
  • Ishida, Morié
  • Wang, Hu
  • Han, Xianlin

publication date

  • September 20, 2025