authors

• Marty, Saci-Elodie
• Yip, Linda
• Wang, Fangyuan
• Manish Kumar, MD
• Fathman, C Garrison

publication date

• October 15, 2025

published in

• Frontiers in immunology  Journal

has subject area

• Animals
• Autoimmune Diseases
• Autoimmunity
• Humans
• NEDD8 Protein
• Receptors, Interleukin-2
• Signal Transduction
• T-Lymphocytes, Regulatory
• Ubiquitin-Protein Ligases
• Ubiquitination

Keywords

• GRAIL
• IL-2 receptorsignaling
• cullin ring ligases (CRLs)
• neddylation
• neddylation activating enzyme inhibitor (NAEi)
• pJAK1 degradation
• regulatory T cell (Treg)

Digital Object Identifier (DOI)

• https://doi.org/10.3389/fimmu.2025.1625419

PubMed ID

• 41169371

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