authors

• Haws, Spencer A
• Dudley Lamming, PhD
• Denu, John M
• Liu, Yang
• Green, Cara L
• Chaiyakul, Krittisak
• Mishra, Pragyan
• Babygirija, Reji
• Armstrong, Eric A
• Mehendale, Anusha T
• Ong, Irene M

publication date

• December 17, 2025

published in

• The Journal of biological chemistry  Journal

has subject area

• Amino Acids
• Amino Acids, Essential
• Animals
• Chromatin
• Diet
• Epigenesis, Genetic
• Histones
• Liver
• Male
• Mechanistic Target of Rapamycin Complex 1
• Metabolome
• Methionine
• Mice
• Mice, Inbred C57BL

Keywords

• diet
• epigenetics
• isoleucine
• leucine
• methionine
• multi-omics analysis
• post-translational modification
• posttranslational modification
• protein depletion
• protein restriction

Digital Object Identifier (DOI)

• https://doi.org/10.1016/j.jbc.2025.111074

PubMed ID

• 41419194

start page

end page

volume

• 302

issue

• 2