authors

• Zhu Zhou, PhD
• Ainslie, Garrett R
• Li, Mengyao
• Dinh, Jean
• Zamek-Gliszczynski, Maciej J
• Zhao, Ping
• Paine, Mary F

publication date

• February 2026

published in

• CPT: pharmacometrics & systems pharmacology  Journal

has subject area

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Adult
• Analgesics, Opioid
• Antidiarrheals
• Area Under Curve
• Cytochrome P-450 CYP3A Inhibitors
• Cytochrome P-450 Enzyme Inhibitors
• Drug Interactions
• Female
• Gemfibrozil
• Humans
• Loperamide
• Male
• Models, Biological
• Nonprescription Drugs

Keywords

• PBPK
• P‐glycoprotein
• cytochrome P450
• drug–drug interactions
• inhibition
• loperamide
• opioid

Digital Object Identifier (DOI)

• https://doi.org/10.1002/psp4.70148

PubMed ID

• 41563903

start page

end page

volume

• 15

issue

• 2