Project Summary/Abstract. The overarching goal for the Stephenson Cancer Center (SCC) Oklahoma (OK) TRUST ACCESS Hub is to enhance capacity for increasing cancer screening trials accrual and participation throughout Oklahoma, a highly rural state. Collectively, 85,000 persons aged 45 to 75 years receive healthcare at OK TRUST Affiliate Organization facilities located across the state. Specifically, OK TRUST will implement processes to: 1) Provide leadership and administrative support to conduct Cancer Screening Research Network (CSRN) trials across Affiliate Organizations in the Oklahoma catchment area and participate in shaping the emerging CSRN research agenda; 2) Expand access to and increase enrollment in cancer screening trials by offering the Vanguard study, and future studies, in participants’ home communities and healthcare facilities; and 3) Leverage SCC’s nationally recognized expertise in clinical trials to include regulatory and operational support for cancer screening trials offered in tribal, rural and urban locations statewide.