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REM Sleep Misfires: Intruding Delta Waves Forecast Tau, Amyloid, and Forgetting in Aging. 2025
Charting structural brain asymmetry across the human lifespan. 2025
Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats. 2025
CMV reshapes lymphoid immunity in aging: a single-cell atlas with predictive modeling. 2025
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation. 2025
hicAB 2025
Diminished and altered cellular senescence response in delayed wound healing of aging. 2025
Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer's disease. 2025
An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling. 2025
Harmonization of Structural Brain Connectivity through Distribution Matching. 2025
An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes. 2025
Regional susceptibility of PV interneurons in an hAPP-KI mouse model of Alzheimer's disease pathology. 2025
A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature. 2025
Dietary restriction of individual amino acids stimulates unique molecular responses in mouse liver. 2025
Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy. 2025
β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity. 2025
Early Life Neuroimaging: The Generalizability of Cortical Area Parcellations Across Development. 2025
Centella asiatica 2025
Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids. 2025
Chronic RNA G-quadruplex Accumulation in Aging and Alzheimer's Disease. 2025
Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance. 2025
Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner. 2024
A Subset of Cortical Areas Exhibit Adult-like Functional Network Patterns in Early Childhood. 2024
Haploinsufficiency of lysosomal enzyme genes in Alzheimer's disease. 2024
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19. 2024
Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes. 2024
MethylGPT: a foundation model for the DNA methylome. 2024
Multi-omics analysis in mouse primary cortical neurons reveals complex positive and negative biological interactions between constituent compounds in Centella asiatica. 2024
An Open Competition for Biomarkers of Aging. 2024
Single-cell, spatial, and fate-mapping analyses uncover niche dependent diversity of cochlear myeloid cells. 2024
Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk. 2024
An analysis of RNA quality metrics in human brain tissue. 2024
Identification of lipid senolytics targeting senescent cells through ferroptosis induction. 2024
Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity. 2024
Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice. 2024
Multi-View Integrative Approach For Imputing Short-Chain Fatty Acids and Identifying Key factors predicting Blood SCFA. 2024
Whole genome methylation sequencing in blood from persons with mild cognitive impairment and dementia due to Alzheimer's disease identifies cognitive status. 2024
Assessing neurocognitive maturation in early adolescence based on baby and adult functional brain landscapes. 2024
Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease. 2024
Heart rate variability impairment during sleep in Veterans with REM sleep behavior disorder, traumatic brain injury, and posttraumatic stress disorder: An early potential window into autonomic dysfunction? 2024
Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations. 2024
High-dimensional Ageome Representations of Biological Aging across Functional Modules. 2024
Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging. 2024
Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation. 2024
Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces. 2024
Paradoxical SERCA dysregulation contributes to atrial fibrillation in a model of diet-induced obesity. 2024
Longitudinal Decline of Exercise Capacity in Male and Female Mice. 2024
Quantifying social roles in multi-animal videos using subject-aware deep-learning. 2024
Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease. 2024
Analyzing heterogeneity in Alzheimer Disease using multimodal normative modeling on imaging-based ATN biomarkers. 2024
Study design features increase replicability in cross-sectional and longitudinal brain-wide association studies. 2024
The Role of Alpha-Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria-ER Membranes. 2024
APOE 2024
ATP Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance And Is Depressed in Human Heart Failure. 2024
Dietary isoleucine content defines the metabolic and molecular response to a Western diet. 2024
Methods to Utilize Pulse Wave Velocity to Measure Alterations in Cerebral and Cardiovascular Parameters. 2024
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity. 2024
Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations. 2024
Metastatic site influences driver gene function in pancreatic cancer. 2024
Quantification of healthspan in aging mice: Introducing FAMY and GRAIL. 2024
Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers. 2024
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. 2024
Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons. 2024
Centella asiatica 2024
Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging. 2024
SEX-SPECIFIC IMPACTS OF EARLY LIFE SLEEP DISRUPTION: ETHANOL SEEKING, SOCIAL INTERACTION, AND ANXIETY ARE DIFFERENTIALLY ALTERED IN ADOLESCENT PRAIRIE VOLES. 2024
Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia. 2024
Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection. 2023
In vivo 2023
Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology. 2023
Modulation of neural gene networks by estradiol in old rhesus macaque females. 2023
Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot. 2023
Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain. 2023
Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease. 2023
A ketogenic diet reduces age-induced chronic neuroinflammation in mice Running title: ketogenic diet and brain inflammaging. 2023
Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations. 2023
Exploratory Correlation of The Human Structural Connectome with Non-MRI Variables in Alzheimer's Disease. 2023
Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants. 2023
Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease. 2023
Joint sequence & chromatin neural networks characterize the differential abilities of Forkhead transcription factors to engage inaccessible chromatin. 2023
Reduced Monocyte Proportions and Responsiveness in Convalescent COVID-19 Patients. 2023
OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records. 2023
omicsMIC: a Comprehensive Benchmarking Platform for Robust Comparison of Imputation Methods in Mass Spectrometry-based Omics Data. 2023
Novel automaticity index reveals a cognitive ability-related decline in gait automaticity during dual-task walking. 2023
MidRISH: Unbiased harmonization of rotationally invariant harmonics of the diffusion signal. 2023
In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimer's Disease Models. 2023
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain. 2023
De novo 2023
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia. 2023
Selective effects of estradiol on human corneal endothelial cells. 2023
Cell-type specific EWAS identifies genes involved in HIV pathogenesis and oncogenesis among people with HIV infection. 2023
ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease. 2023
Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease. 2023
Sex-specific declines in cholinergic-targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease. 2023
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. 2023
Potentiated cholinergic and corticofugal inputs support reorganized sensory processing in the basolateral amygdala during auditory threat acquisition and retrieval. 2023
The mitochondrial multi-omic response to exercise training across tissues. 2023
Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets. 2023
Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions. 2020
SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike. 2020
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium. 2020

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