Selected Publications
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article
- Quadriceps mitochondrial DNA quantity, quality, and gene expression after 2 years of calorie restriction: exploratory results from the CALERIE trial.. GeroScience. 2026
- Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: four core genotypes and more.. Biology of sex differences. 2026
- Sry. bioRxiv : the preprint server for biology. 2025
- Cognitive Impairment Highly Prevalent and Associated With Reduced Physical Function in Older Veteran Clinical Exercise Program.. Archives of rehabilitation research and clinical translation. 7:-. 2025
- Mitochondrial haplotype and sex modulate responses to endurance exercise training.. The Journal of physiology. 2025
- Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males.. Cell reports. Medicine. 6:-. 2025
- Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia.. bioRxiv : the preprint server for biology. 2025
- Chimeric mitochondrial RNA transcripts predict mitochondrial genome deletion mutations in mitochondrial genetic diseases and aging.. Genome research. 35:55-65. 2025
- Mitochondrial DNA Deletion Mutations: A Molecular Cause of Age-Induced Skeletal Muscle Fiber Dysfunction and Fiber Death Contributing to Sarcopenia.. Advances in experimental medicine and biology. 343-363. 2025
- Increased mitochondrial mutation heteroplasmy induces aging phenotypes in pluripotent stem cells and their differentiated progeny.. Aging cell. 24:-. 2024
- Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats.. GeroScience. 47:851-862. 2024
- Improvement in the sensitivity of LA-ICP-MS bioimaging by addition of nitrogen to the argon carrier gas.. Journal of analytical atomic spectrometry. 39:1720-1725. 2024
- Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria.. Science advances. 10:-. 2024
- Immunolabelling perturbs the endogenous and antibody-conjugated elemental concentrations during immuno-mass spectrometry imaging.. Analytical and bioanalytical chemistry. 416:2725-2735. 2023
- A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes.. The journals of gerontology. Series A, Biological sciences and medical sciences. 78:771-779. 2023
- Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging.. Aging cell. 22:-. 2023
- Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short report.. PloS one. 17:-. 2022
- Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles.. GeroScience. 45:555-567. 2022
- Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation.. Mitochondrion. 176-183. 2022
- Metformin Treatment in Old Rats and Effects on Mitochondrial Integrity.. Rejuvenation research. 24:434-440. 2021
- Baseline pro-inflammatory gene expression in whole blood is related to adverse long-term outcomes after transcatheter aortic valve replacement: a case control study.. BMC cardiovascular disorders. 21:-. 2021
- Assessing the reproducibility of labelled antibody binding in quantitative multiplexed immuno-mass spectrometry imaging.. Analytical and bioanalytical chemistry. 413:5509-5516. 2021
- Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women.. GeroScience. 43:1253-1264. 2021
- Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin.. Scientific reports. 11:-. 2021
- Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge.. Aging cell. 19:-. 2020
- Mitochondrial DNA deletion mutations increase exponentially with age in human skeletal muscle.. Aging clinical and experimental research. 33:1811-1820. 2020
- A well-tolerated core needle muscle biopsy process suitable for children and adults.. Muscle & nerve. 62:688-698. 2020
- Polg1. Science translational medicine. 12. 2020
- 9. Cells. 9. 2020
- mdx. Frontiers in physiology. -. 2020
- A novel approach to measure mitochondrial respiration in frozen biological samples.. The EMBO journal. 39:-. 2020
- Enhanced Methods for Needle Biopsy and Cryopreservation of Skeletal Muscle in Older Adults.. Journal of cytology & histology. 11. 2020
- Super-Resolution Reconstruction for Two- and Three-Dimensional LA-ICP-MS Bioimaging.. Analytical chemistry. 91:14879-14886. 2019
- Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice.. Mechanisms of ageing and development. -. 2019
- Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.. Experimental gerontology. -. 2019
- Long term rapamycin treatment improves mitochondrial DNA quality in aging mice.. Experimental gerontology. 125-131. 2018
- Digital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes.. The journals of gerontology. Series A, Biological sciences and medical sciences. 72:1327-1333. 2017
- Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age.. Aging cell. 15:1132-1139. 2016
- Mitochondrial quality control in insulin resistance and diabetes.. Current opinion in genetics & development. 118-126. 2016
- Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.. Science translational medicine. 8:-. 2016
- Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice.. Experimental gerontology. 15-9. 2014
- Single Cell Multiplex Protein Measurements through Rare Earth Element Immunolabeling, Laser Capture Microdissection and Inductively Coupled Mass Spectrometry.. Journal of cytology & histology. 5. 2014
- HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle.. Diabetes. 63:1488-505. 2013
- Divergent mitochondrial biogenesis responses in human cardiomyopathy.. Circulation. 127:1957-67. 2013
- Mitochondrial oxidative stress and mammalian healthspan.. Mechanisms of ageing and development. 131:527-35. 2010
- Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer.. Environmental and molecular mutagenesis. 51:427-39. 2010
- Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria.. Aging cell. 9:536-44. 2010
- A mitochondrial view of aging, reactive oxygen species and metastatic cancer.. Aging cell. 9:462-5. 2010
- On mitochondria, mutations, and methodology.. Cell metabolism. 10:-. 2009
- DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.. Nature genetics. 40:392-4. 2008
- Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells.. American journal of physiology. Renal physiology. 292:F1751-60. 2007
- Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats.. American journal of physiology. Heart and circulatory physiology. 290:H304-11. 2005
- Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia.. Journal of applied physiology (Bethesda, Md. : 1985). 92:2617-24. 2002
- Mitochondrial DNA deletion mutations and sarcopenia.. Annals of the New York Academy of Sciences. 412-23. 2002
- Age-associated changes in function, structure and mitochondrial genetic and enzymatic abnormalities in the Fischer 344 x Brown Norway F(1) hybrid rat heart.. Journal of molecular and cellular cardiology. 34:17-28. 2002
- Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection.. Nucleic acids research. 29:4502-8. 2001
- Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15:322-32. 2001
- Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates.. Toxicological sciences : an official journal of the Society of Toxicology. 52:35-40. 1999
- Molecular and cellular biology of interleukin-6 and its receptor.. Frontiers in bioscience : a journal and virtual library. d340-57. 1996