Head of
- Penn Medical Communication Research Institute Director 2021 -
- Contact Info
Anne R. Cappola, MD, ScM
Positions
- Director/Co-Director, University of Pennsylvania
- Professor, University of Pennsylvania
Location
-
Philadelphia, PA
Clinical Disciplines
- Affiliation
- Publications
- Research
- Other
- View All
Affiliation
Publications
Selected Publications
-
article
- Counseling Adolescents About Intrauterine Device Insertional Pain in the Social Media Era: Reproductive Justice Principles.. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. 75:849-850. 2024
-
Trends in visits, imaging, and diagnosis for emergency department abdominal pain presentations in the United States, 2007-2019..
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
2024
- Association of Thyroid Dysfunction in Individuals ≥ 65 Years of Age With Subclinical Cardiac Abnormalities.. The Journal of clinical endocrinology and metabolism. 109:e1847-e1856. 2024
-
Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy..
Nature communications.
15:-.
2024
- Double malnutrition and associated factors in a middle-aged and older, rural South African population.. BMC nutrition. 10:-. 2024
-
Improving Medical Communication-Reply..
JAMA.
331:-.
2024
-
Misinformation and the Vaccine Adverse Event Reporting System..
JAMA.
331:1005-1006.
2024
-
Communicating Medicine-A New JAMA Series..
JAMA.
331:-.
2024
-
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications..
Nature communications.
15:-.
2024
- Using Natural Language Processing to Extract and Classify Symptoms Among Patients with Thyroid Dysfunction.. Studies in health technology and informatics. 614-618. 2024
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Strategies to Improve Medical Communication..
JAMA.
331:70-71.
2024
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The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis..
The lancet. Diabetes & endocrinology.
11:743-754.
2023
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Hormones and Aging: An Endocrine Society Scientific Statement..
The Journal of clinical endocrinology and metabolism.
108:1835-1874.
2023
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Barriers to and solutions for representative inclusion across the lifespan and in life course research: The need for structural competency highlighted by the COVID-19 pandemic..
Journal of clinical and translational science.
7:-.
2022
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Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies..
European journal of endocrinology.
187:S35-S46.
2022
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Changes in the Hierarchy of Functional Impairment From Middle Age to Older Age..
The journals of gerontology. Series A, Biological sciences and medical sciences.
77:1577-1584.
2022
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Sex Differences in Recovery Across Multiple Domains Among Older Adults With Hip Fracture..
The journals of gerontology. Series A, Biological sciences and medical sciences.
77:1463-1471.
2022
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Addressing Online Health Privacy Risks for Older Adults: A Perspective on Ethical Considerations and Recommendations..
Gerontology & geriatric medicine.
-.
2022
-
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies..
Frontiers in psychiatry.
-.
2022
-
Challenges in the Management of Atrial Fibrillation With Subclinical Hyperthyroidism..
Frontiers in endocrinology.
-.
2022
-
Subclinical hypothyroidism in older individuals..
The lancet. Diabetes & endocrinology.
10:129-141.
2021
- Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer.. Nature communications. 12:-. 2021
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Osteoporosis, Rather Than Sarcopenia, Is the Predominant Musculoskeletal Disease in a Rural South African Community Where Human Immunodeficiency Virus Prevalence Is High: A Cross-Sectional Study..
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
37:244-255.
2021
-
Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis..
JAMA internal medicine.
181:1440-1450.
2021
-
Evaluation and disposition of older adults presenting to the emergency department with abdominal pain..
Journal of the American Geriatrics Society.
70:501-511.
2021
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Sex-specific 25-hydroxyvitamin D threshold concentrations for functional outcomes in older adults: PRoject on Optimal VItamin D in Older adults (PROVIDO)..
The American journal of clinical nutrition.
114:16-28.
2021
-
Autoimmune Thyroid Disease in Women..
JAMA.
325:2392-2393.
2021
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Effect of Targeted Messaging on Return to In-Person Visits During the COVID-19 Pandemic: A Randomized Clinical Trial..
JAMA network open.
4:-.
2021
-
Cortisol and Dehydroepiandrosterone Response to Adrenocorticotropic Hormone and Frailty in Older Women..
The journals of gerontology. Series A, Biological sciences and medical sciences.
76:901-905.
2021
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The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues..
JAMA.
325:1401-1402.
2021
-
Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document..
European thyroid journal.
10:10-38.
2021
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Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document..
Thyroid : official journal of the American Thyroid Association.
31:156-182.
2021
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An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms..
Scientific reports.
10:-.
2020
-
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer..
Nature communications.
11:-.
2020
-
Letter to the Editor: "Our Response to COVID-19 as Endocrinologists and Diabetologists"..
The Journal of clinical endocrinology and metabolism.
105.
2020
-
Editorial: Combination Therapy for Hypothyroidism: The Journey From Bench to Bedside..
Frontiers in endocrinology.
-.
2020
-
Continuous Glucose Monitoring in Adolescent, Young Adult, and Older Patients With Type 1 Diabetes..
JAMA.
323:2384-2385.
2020
-
Design of the Optimal Trial of Combination Therapy..
Frontiers in endocrinology.
-.
2020
-
The Thyrotropin Reference Range Should Be Changed in Older Patients..
JAMA.
322:1961-1962.
2019
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Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism..
Thyroid : official journal of the American Thyroid Association.
29:1359-1363.
2019
-
Thyroid Function Test Abnormalities During Pregnancy..
JAMA.
322:617-619.
2019
- Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies.. BMJ open. 9:-. 2019
-
Subclinical Hypothyroidism: A Review..
JAMA.
322:153-160.
2019
-
Thyroid and Cardiovascular Disease Research Agenda for Enhancing Knowledge, Prevention, and Treatment..
Circulation.
139:2892-2909.
2019
-
Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment..
Thyroid : official journal of the American Thyroid Association.
29:760-777.
2019
-
Low thyroid function is not associated with an accelerated deterioration in renal function..
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
34:650-659.
2019
- Response by Cappola and Cappola to Letter Regarding Article, "Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes".. Circulation. Heart failure. 12:-. 2019
-
Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study..
JAMA cardiology.
4:144-152.
2019
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Association of Biomarker and Physiologic Indices With Mortality in Older Adults: Cardiovascular Health Study..
The journals of gerontology. Series A, Biological sciences and medical sciences.
74:114-120.
2019
-
Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes..
Circulation. Heart failure.
11:-.
2018
- Taste Perception and Water Swallow Screen Results in Old-Old Women.. Geriatrics (Basel, Switzerland). 3. 2018
-
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation..
Nature communications.
9:-.
2018
-
The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data..
The Journal of clinical endocrinology and metabolism.
103:3658-3667.
2018
-
Clinical aspects of thyroid function during ageing..
The lancet. Diabetes & endocrinology.
6:733-742.
2018
-
Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study..
The journals of gerontology. Series A, Biological sciences and medical sciences.
73:953-959.
2018
-
Diagnostic Accuracy of Ultrasound With Color Flow Doppler in Children With Thyroid Nodules..
The Journal of clinical endocrinology and metabolism.
103:1958-1965.
2018
-
An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction..
Thyroid : official journal of the American Thyroid Association.
28:707-721.
2018
- The Association Between IGF-I and IGFBP-3 and Incident Diabetes in an Older Population of Men and Women in the Cardiovascular Health Study.. The Journal of clinical endocrinology and metabolism. 102:4541-4547. 2017
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Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation..
Circulation.
136:2100-2116.
2017
-
Defining Optimal Health Range for Thyroid Function Based on the Risk of Cardiovascular Disease..
The Journal of clinical endocrinology and metabolism.
102:2853-2861.
2017
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Thyroid Function Tests in the Reference Range and Fracture: Individual Participant Analysis of Prospective Cohorts..
The Journal of clinical endocrinology and metabolism.
102:2719-2728.
2017
-
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations..
PLoS genetics.
13:-.
2017
-
How to Look for Thyroid Cancer..
JAMA.
317:1840-1841.
2017
- Response to the Letter by Choy.. The Journal of clinical endocrinology and metabolism. 102:1409-1410. 2017
-
Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study..
Alzheimer disease and associated disorders.
31:107-113.
2017
- Insulinlike Growth Factor Binding Protein-1 and Ghrelin Predict Health Outcomes Among Older Adults: Cardiovascular Health Study Cohort.. The Journal of clinical endocrinology and metabolism. 102:267-278. 2017
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Thyroid-Stimulating Hormone in the Evaluation of Subclinical Hypothyroidism..
JAMA.
316:1592-1593.
2016
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Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis..
The Journal of clinical endocrinology and metabolism.
101:4270-4282.
2016
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Osteoporosis Therapy in Postmenopausal Women With High Risk of Fracture..
JAMA.
316:715-6.
2016
-
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits..
Aging cell.
15:811-24.
2016
-
Conflict or Confluence of Interest?--Reply..
JAMA.
315:1793-4.
2016
-
The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones..
International journal of endocrinology.
-.
2015
-
Confluence, Not Conflict of Interest: Name Change Necessary..
JAMA.
314:1791-2.
2015
-
Relationship between Carotenoids, Retinol, and Estradiol Levels in Older Women..
Nutrients.
7:6506-19.
2015
-
Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts..
JAMA internal medicine.
175:1037-47.
2015
-
Subclinical thyroid dysfunction and fracture risk: a meta-analysis..
JAMA.
313:2055-65.
2015
-
Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis..
The Journal of clinical endocrinology and metabolism.
100:2181-91.
2015
-
Improving the long-term management of benign thyroid nodules..
JAMA.
313:903-4.
2015
-
Thyroid function in the euthyroid range and adverse outcomes in older adults..
The Journal of clinical endocrinology and metabolism.
100:1088-96.
2014
- Effects of transdermal testosterone treatment on inflammatory markers in elderly males.. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 20:1170-7. 2014
-
Levothyroxine prescription: not as simple as it seems..
JAMA.
311:2532-3.
2014
-
Controlling the metabolic roller coaster in diabetes..
JAMA.
311:2277-8.
2014
-
Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease: an individual participant data analysis..
The Journal of clinical endocrinology and metabolism.
99:3353-62.
2014
-
Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: the cardiovascular health study..
The Journal of clinical endocrinology and metabolism.
99:2657-64.
2014
-
Testosterone, dihydrotestosterone, and incident cardiovascular disease and mortality in the cardiovascular health study..
The Journal of clinical endocrinology and metabolism.
99:2061-8.
2014
-
Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study..
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
24:186-93.
2014
-
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease..
PLoS genetics.
10:-.
2014
- Meta-analysis of loci associated with age at natural menopause in African-American women.. Human molecular genetics. 23:3327-42. 2014
-
Subclinical hypothyroidism, weight change, and body composition in the elderly: the Cardiovascular Health Study..
The Journal of clinical endocrinology and metabolism.
99:1220-6.
2014
-
Modeling Bivariate Longitudinal Hormone Profiles by Hierarchical State Space Models..
Journal of the American Statistical Association.
109:108-118.
2014
-
Testosterone therapy and risk of cardiovascular disease in men..
JAMA.
310:1805-6.
2013
-
Physical performance and frailty in chronic kidney disease..
American journal of nephrology.
38:307-15.
2013
- Aging and endocrinology. Preface.. Endocrinology and metabolism clinics of North America. 42:xvii-xviii. 2013
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Clinical review: The human experience with ghrelin administration..
The Journal of clinical endocrinology and metabolism.
98:1826-37.
2013
-
Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study..
The Journal of clinical endocrinology and metabolism.
98:533-40.
2012
-
Factors impacting the departure rates of female and male junior medical school faculty: evidence from a longitudinal analysis..
Journal of women's health (2002).
21:1059-65.
2012
-
Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study..
The Journal of clinical endocrinology and metabolism.
97:3944-50.
2012
-
The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study..
The Journal of clinical endocrinology and metabolism.
97:1962-9.
2012
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Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trial..
Annals of family medicine.
10:15-22.
2012
-
Dehydroepiandrosterone sulfate and postmenopausal women..
Current opinion in endocrinology, diabetes, and obesity.
18:171-6.
2011
-
Predictors of thyroid hormone initiation in older adults: results from the cardiovascular health study..
The journals of gerontology. Series A, Biological sciences and medical sciences.
66:809-14.
2011
-
Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: the cardiovascular health study..
The Journal of clinical endocrinology and metabolism.
96:989-96.
2011
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Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial..
Fertility and sterility.
94:2161-6.
2010
-
Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study..
Journal of the American Geriatrics Society.
58:421-6.
2010
-
Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease..
The Journal of clinical endocrinology and metabolism.
94:4776-84.
2009
- Examining faculty awards for gender equity and evolving values.. Journal of general internal medicine. 25:57-60. 2009
- Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study.. The journals of gerontology. Series A, Biological sciences and medical sciences. 64:1268-74. 2009
- Mindfulness Based Stress Reduction: effect on emotional distress in diabetes.. Practical diabetes international : the journal for diabetes care teams worldwide. 26:222-224. 2009
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Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies..
The journals of gerontology. Series A, Biological sciences and medical sciences.
64:243-8.
2009
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High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over..
The Journal of clinical endocrinology and metabolism.
94:1342-5.
2009
- Work-life policies for faculty at the top ten medical schools.. Journal of women's health (2002). 17:1311-20. 2008
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The intersection of cancer and aging: establishing the need for breast cancer rehabilitation..
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
16:866-72.
2007
-
Determinants of serum total and free testosterone levels in women over the age of 65 years..
The Journal of clinical endocrinology and metabolism.
92:509-16.
2006
-
DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I..
The journals of gerontology. Series A, Biological sciences and medical sciences.
61:957-62.
2006
-
Thyroid status, cardiovascular risk, and mortality in older adults..
JAMA.
295:1033-41.
2006
- Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus.. The American journal of cardiology. 97:651-4. 2006
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Hypothyroidism and atherosclerosis..
The Journal of clinical endocrinology and metabolism.
88:2438-44.
2003
Research
Principal Investigator on
- Levothyroxine Dosing in Older Individuals 2023 - 2028
- T4/T3 Therapy in Hypothyroidism 2024 - 2027
- Diabetes, Endocrine, and Metabolism 1978 - 2026
- Midcareer Investigator Award in Patient-Oriented Research in Aging 2013 - 2025
- Developing Oral LT3 Therapy for Heart Failure 2019 - 2024
- Diabetes, Endocrine and Metabolic Disease 1978 - 2021
- Diabetes, Endocrine, and Metabolic Disease 1978 - 2016
- Ghrelin and Strength Training in Frail Elderly 2011 - 2014
- Subclinical thyroid dysfunction in the elderly 2009 - 2014
- Hormonal trajectories in aging 2006 - 2012
- Androgens, Myostatin, and Sarcopenia in Older Women 2002 - 2007
Other
Available to Provide Advice to Those
Available to be Contacted for
Areas of Focus
- Endocrinology
- Frailty and resilience
- Epidemiology